【摘要】 咳嗽高敏感综合征(CHS)是指与咳嗽反射高敏性相关、不能用其他原因解释的慢性咳嗽。大多数特发性慢性咳嗽都可归入CHS。CHS有多种不同表型,包括与自体免疫病相关的CHS、与维生素B12缺乏相关的CHS、"9.11世贸中心咳嗽综合征"等。本文综述CHS的概念、临床特征及研究进展,介绍CHS涉及的咳嗽反射敏感性及与其他过敏综合征的关系。更多还原

【Abstract】 Cough hypersensitivity syndrome(CHS) has been proposed as a term for patients with chronic cough associated with cough reflex hypersensitivity that can’t be explained by other causes. A majority of patients with idiopathic chronic cough(ICC) can be explained with CHS. Within CHS it is likely that there will be many phenotypes, including CHS associated autoimmune diseases, CHS associated vitamin B-12 deficiency, and "9.11 World Trade Center cough syndrome". The concept, clinical features and research development of CHS is described in this review. The associated knowledge of cough reflex, cough hypersensitivity and the potential link of CHS and other hypersensitivity syndrome are herein introduced too.更多还原