Objective To synthesize 7-hydroxy-α,β-dibenzyl-γ-butyrolactone lignans and evaluate their anti-inflammatory activity. Methods Fifteen compounds( 7a- 7o) were designed and synthesized,the structures of which were confirmed by MS and1H-NMR. Topical anti-inflammatory activities were assayed using croton oil induced ear oedema test in mice. Results Most of the target compounds could inhibit ear oedema of the mice. Compound 7e exhibited the best oedema-inhibiting effect with an inhibition rate of 60. 5%,which wa...
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