【摘要】 P53是一种重要的肿瘤抑制基因,研究发现P53对胚胎干细胞(ESCs)的分化也有重要影响。P53与其下游靶点P21结合及ESCs的核仁蛋白缺失可上调P53,促使G1期延长,诱导ESCs走向分化;而高HIF-2α低P53状态及Aurka-P53信号轴可维持细胞干性,抑制分化。更多还原

【Abstract】 The P53 is a key tumor suppressor. Many studies have shown that P53 plays an important role in inducing ESCs differentiation. P53 binding with P21,which is one of transcriptional targets of the P53,and knockdown of nucleolin induce cell cycle arrest,G1 phase accumulation and differentiation in ESCs by up-regulating P53 protein level; Moreover,HIF-2α high expression inhibiting P53 activity and promoting Aurora Kinase-P53 Signaling can maintain the "stemness"and inhibit differentiation.更多还原