【摘要】 慢性氧化应激与许多视网膜病变相关疾病发生相关。氧化应激引起视网膜色素上皮(RPE)胞内蛋白质、脂质、DNA以及细胞器损伤,导致RPE功能紊乱。目前,RPE氧化应激的分子机制及其调控过程尚不清楚。最近研究发现,一些重要的分子伴侣、转录因子以及microRNAs参与了RPE抗氧化应激过程的调控,这些发现为视网膜病变相关疾病治疗策略的制定提供了新思路。更多还原

【Abstract】 Chronic oxidative stress is involved in the development of many retinal degenerative-related diseases.Oxidative stress may induce the damages of proteins,lipids,DNA and organelles in retinal pigment epithelial( RPE),and cause RPE cellular dysfunction. So far,the molecular mechanism and regulatory process of oxidative stress in RPE still remain unclear. Recent studies found that some of molecular chaperones,transcription factors and microRNAs play a critical role in protection against oxidative stress in RPE,which may provide new therapeutic strategies for retinal degenerative-related diseases.更多还原