【摘要】 目的 评价当归承气汤对躁狂发作的临床疗效和安全性。方法 应用随机、双盲、病例对照研究方法,将123例患者随机分成当归承气汤组41例、单用碳酸锂组42例和当归承气汤合并碳酸锂组40例,单药组联合应用另一种药物的安慰剂,疗程8周,在治疗前、治疗后2,4,8周末时,采用Young氏躁狂量表(YMRs)、治疗不良反应量表(TEsS)及自拟中医症候量表等进行评定。结果 单用当归承气汤患者总疗效(46.34%)比单独使用碳酸锂(80.49%)或两药舍用(86.84%)低,3组间比较差异有统计学意义(χ~2=41.43,P<0.01)。3组自拟中医症候量表评分比较,各组治疗后2,4,8周自拟中医症候量表总分与治疗前比较差异有统计学意义(P<0.01);3组之间两两比较,治疗2周后当归承气汤组与合用组、碳酸锂组与合用组比较差异有统计学意义(P<0.01),治疗4周后当归承气汤组与合用组差异有统计学意义(P<0.05),3组在治疗后8周量表总分两两比较差异均有统计学意义(P<0.05);当归承气汤组不良反应发生率明显低于碳酸锂组与舍用组(P<0.01)。结论 当归承气汤合并碳酸锂治疗躁狂发作疗效好、安全性高、值得临床推广应用。更多还原

【Abstract】 Objective To observe the efficacy and safety of Danggui-Chengqi Decoction in treatment of mania patients.Methods Totals of 123 patients meeting the criteria of CCMD-3 for mania were randomly divided into three groups,the lithium carbonate group(n = 42),the Danggui- Chengqi decoction group(n = 41) and the Danggui- Chengqi decoction combined with lithium carbonate group(the combined group,n = 40),mania patients were gaven Danggui-Chengqi decoction and lithium carbonate and placebo respectively,they were treated for 8 weeks.Clinical efficacy and the safety were evaluated with Young Mania Rating Scale(YRMS) and Traditional Chinese medicine symptom scale and Treatment Emergent Symptom Scale(TESS)separately.Results The therapeutic effect rate of Danggui-Chengqi decoction group was 46.34%,which was lower than lithium carbonate group(80.49%) and combined group(86.84%),and the difference was significant(χ~2 = 41.43,P< 0.01).At the end of 2th,4th,8th week after treatment,the total scores of Traditional Chinese medicine symptom scale were all showed significantly increased in each group compared with that before treatment(P < 0.01);the comparations were conducted between any two groups,there were significant differences at the end of 2th week after treatment between the Danggui-Chengqi decoction group or lithium carbonate group and combined group(P<0.01),there were significant differences at the end of 4th week after treatment between the Danggui-Chengqi decoction group and combined group(P < 0.05),there were significant differences at the end of 8th week after treatment between any two groups(P < 0.01).Treatment emergent symptoms rate in Danggui- Chengqi decoction group was lower than lithium carbonate group and combined group(P < 0.01).Conclusions It is effective and safe to treat mania using Danggui-Chengqi decoction combined with lithium carbonate,which is worthy to populize and applicate in clinic.更多还原