【摘要】 目的 探讨听觉事件相关电位(ERP)P300与强迫症患者各项指标的相关性。方法 将63例强迫症患者作为研究组,选取63名身心健康正常人为对照组,采用自制的一般状况调查表了解两组人员的基本情况,对两组人员分别进行事件相关电位P300的检测,对强迫症患者采用耶鲁布朗强迫症量表评估其病情。结果 研究组ERP各项指标中N2、P3潜伏期长于对照组(t分别为-1.568,-2.602;P<0.05),N1、P2、N2、P3波幅均小于对照组(t分别为2.505,2.646,3.029,4.904;P<0.05)。强迫思维组N2、P3潜伏期长于强迫行为组(t分别为3.301,2.580;P<0.05),P3波幅低于强迫行为组(t=-5.240,P<0.01)。经相关分析显示事件相关电位P300的P3波幅与强迫思维分及强迫行为分呈负相关(r分别为-0.384,-0.512;P<0.05),N2和P3潜伏期均与强迫思维分呈正相关(r分别为0.448,0.405;P<0.05)。结论 听觉事件相关电位P300可以客观反映强迫症的认知功能。更多还原

【Abstract】 Objective To explore the relationship between the auditory event related potential P300 and the indexes in patients with obsessive-compulsive disorder(OCD).Methods Totals of 63 patients with OCD were recruited as study group and 63 healthy as control group.The self-designed questionnaire of general condition was administrated to evaluate the basic condition of both groups.Both groups were tested by auditory event related potential P300.Obsessive-compulsive symptoms were assessed with the Yale-Brown Obsessive-compulsive Scale(YBOCS).Results In the ERP indicators of study group,the latencies of N2 and P3 were longer than that in the control group it =- 1.568,-2.602,respectively;P < 0.05),and the amplitude of N1、P2、N2、P3 were lower than the control group it = 2.505,2.646,3.029,4.904,respectively;P<0.05).The latency of N2 and P3 in obsessive thinking group were significantly longer than the compulsive behavior group it = 3.301,2.580,respectively;P < 0.05),and the amplitude of P3 were significantly smaller than the compulsive behavior group it =-5.240,P < 0.01).The correlation analysis showed that the P3 amplitude were significantly negatively correlated with obsessive thinking points and behavior points(r =- 0.384,-0.512,respectively;P <0.05).The latencies of N2 and P3 were significantly positively correlated with obsessive thinking points(r = 0.448,0.405,respectively;P < 0.05).Conclusions The auditory event-related potentials P300 can objectively predict the OCD cognitive function.更多还原