【摘要】 芋螺毒素由芋螺毒液管和毒囊内壁的毒腺所分泌,每种芋螺的毒液中至少含50~200种活性多肽。根据芋螺毒素高度保守的信号肽序列及二硫键骨架,芋螺毒素分为A、B1、B2、B3、C、D、E、F、G、H、I1、I2、I3、J、K、L、M、N、O1、O2、O3、P、S、T、V、Y等26个超家族。目前对A、O、M等超家族芋螺毒素研究较多,但新近发现的S、I、J、C、D、B1、B3、V、Y等超家族芋螺毒素的结构及功能报道较少,这些超家族具有复杂的翻译后修饰和独特的半胱氨酸骨架。本文对新近发现的S、I、J、C、D、B1、B3、V、Y等超家族芋螺毒素的序列、结构、作用靶点及功能进行简要综述。更多还原

【Abstract】 Conotoxins are secreted by the duct and theca of Cone snail,about 50~200bioactive peptides exist in the venom of Cone snail.According to the highly conserved signal peptide sequences,conotoxins can be divided into A-,B1-,B2-,B3-,C-,D-,E-,F-,G-,H-,I1-,I2-,I3-,J-,K-,L-,M-,N-, O1-,O2-,O3-,P-,S-,T-,V-and Y-superfamilies,etc.A-,O-,M-superfamily conotoxins have been well characterized and reviewed.Some novel conotoxins,such as S-,I-,J-,C-,D-,B1-,B3-,V-,Ysuperfamily,have been found recently,and exhibit complicated post-translational modifications and novel cysteine frameworks.This review briefly summarizes the progress of the studies on the sequence characters,structures,targets and functions of those novel conotoxins.更多还原