【摘要】 通过RAFT合成聚(甲基丙烯酸缩水甘油酯)-b-聚(乙二醇甲基丙烯酸酯)嵌段共聚物(PGMA-bPMAPEG),再用半胱氨酸(Cys)使PGMA中的环氧基团开环,制备含有巯基的两亲水嵌段聚合物PMAPEG-bP(GMA-Cys)。并以其作为修饰剂,通过原位还原法使HAuCl4在NaBH4的还原下制备金/聚合物纳米复合粒子(Au@PMAPEG-b-P(GMA-Cys)NPs)。经FT-IR、UV-vis、TG、XRD、TEM和DLS表征,发现金纳米复合粒子呈均匀分散的球形,平均粒径约为10nm,在527nm处出现了金纳米粒子的表面等离子共振吸收峰,金约占总重量的49%。由于外层嵌段共聚物的修饰作用,金纳米复合粒子在室温下放置6个月未发生粒子间的聚集。更多还原

【Abstract】 The diblock copolymer of poly( 2,3-epoxypropyl methacrylate glycidyl methacrylate)-b-poly( poly( ethylene glycol) methylether methacrylate)( PGMA-b-PMAPEG) was prepared by reversible addition-fragmentation chain transfer( RAFT) polymerization. Then thiol-functionalized polymer PMAPEG-b-P( GMA-Cys) was synthesized by the reaction of cysteine( Cys) with the epoxy groups of PGMA. Furthermore,using MAPEG-b-P( GMA-Cys) as a modifier,Au@ PMAPEG-b-P( GMA-Cys) NPs has been synthesized by in-situ reduction of HAuCl4 with sodium borohydride( NaBH4) as a reductant. The gold nanocomposite particles were characterized by UV-visible( UV-vis),fourier transform infrared spectroscopy( FT-IR),thermal gravimetric analysis( TGA),X-Ray diffraction( XRD),transmission electron microscopy( TEM) and dynamic light scattering( DLS),found that the gold nanocomposite particles were uniformly dispersed spherical and the average size was about 10 nm. UV-visible spectra displayed that the surface plasma resonance absorption peak appeared at about 527 nm for gold nanocomposite particles. The TGA curves indicated that the percentage of gold in the gold nanocomposite particles is 49%. The gold composite particles did not occur aggregation between particles at room temperature over six months because the modification of the outer block copolymer.更多还原