【摘要】 多甲氧基菲-9-甲酸及酯是合成娃儿藤生物碱及其类似物的关键中间体。实验发现,以DTBP作为氧化剂,CaCl2存在下,能有效提高分子内氧化偶联合成多甲氧基菲-9-甲酸及酯产率,且反应条件温和,后处理方便,为合成许多重要化合物前体菲提供了一种新的思路。更多还原

【Abstract】 Polymethoxy-substituted phenanthrene-9-carboxylic acid or methylate is key intermediate for synthesis of tylophora alkaloids and analogues. Experiments showed that intramolecular oxidative coupling reaction of building polymethoxy-substituted phenanthrene-9-carboxylic acid or methylate by DTBP / CaCl2gave good yields. The mild reaction condition,and easy post-treatment of this method provided us a new approach for the synthesis of phenanthrene ring.更多还原