【摘要】 在头孢噻肟钠溶析结晶过程中,容易发生胶凝。为了控制结晶过程,避免胶凝,使用在线技术考察了3种晶种以及超声波对头孢噻肟钠结晶过程的影响。结果表明,晶种不仅影响产品的粒度分布和晶习,还会影响产品收率以及纯度。研磨晶种能够有效促进成核,显著消耗过饱和度,从而抑制胶凝的发生,促进头孢噻肟钠结晶。超声波也能起到促进成核的作用。研磨晶种的比表面积较大且表面粗糙是其有效诱导头孢噻肟钠结晶的重要因素。更多还原

【Abstract】 Cefotaxime sodium is easy to gelate during anti-solvent crystallization. Aiming at controlling crystallization process and avoiding gelation,different seeds were used to investigate their effects on the anti-solvent crystallization of cefotaxime sodium. The effect of ultrasonic on the crystallization process was also investigated. Crystallization process was monitored using process analytical technologies. The results show that the seeds affect not only the crystal size distribution and crystal shape,but also the crystal purity and yield. The milled seeds can effectively induce nucleation and crystal growth,consume the supersaturation and then avoid gelation. The ultrasonic can induce nucleation as well. The results also shows that specific surface area and surface roughness of the seed crystal are the key factors inducing crystallization of cefotaxime sodium.更多还原