Objective To explore the clinical significance of prenatal gene diagnosis of severe thalassemia.Methods Eighty-six pregnant women with thalassemia,whose husband had the same type of thalassemia,were detectedα-thalassemia by Gap-PCR and PCR-reverse dot blot(PCR-RDB),and were detectedβ-thalassemia by PCR-RDB.Results In 86 women,normal genotype was found in 14(16.28%),α-thalassemia in 55(63.95%)including 7Bart's fetuses,β-thalassemia in 15cases(17.44%)including 4severeβ-thalassemia fetuses,andαβmixed thalassem...
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