【摘要】 目的探讨检测血清降钙素原(procalcitonin,PCT)与高敏C反应蛋白(high sensitivity C-reactive protein,hsCRP)对新生儿脓毒血症的早期诊断价值。方法脓毒血症新生儿33例(脓毒血症组),局部感染新生儿41例(局部感染组),非感染新生儿38例(非感染组),采用电化学发光法测定3组血清PCT水平,采用免疫比浊法测定3组血清hsCRP水平,并进行比较。结果脓毒血症组、局部感染组、非感染组血清PCT分别为(12.30±11.60)、(0.26±0.25)、(0.09±0.07)μg/L,血清hs-CRP水平分别为(22.50±20.10)、(3.21±3.06)、(0.85±0.33)mg/L,3组血清PCT和hsCRP水平比较差异有统计学意义(P<0.05)。诊断新生儿脓毒血症的敏感性和特异性PCT为84.8%和96.2%,hsCRP为87.9%和86.1%。结论检测血清PCT和hs-CRP有助于新生儿脓毒血症的早期诊断。更多还原

【Abstract】 Objective To explore the value of serum procalcitonin(PCT)and high sensitivity C-reactive protein(hsCRP)to the diagnosis of early neonatal sepsis.Methods The serum PCT and hs-CRP levels were detected by electrochemical luminescence method and immuneturbidimetric test respectively and were compared in 33cases of neonatal sepsis(sepsis group),41cases of neonatal local infection(infection group)and 38 newborns with no infection(noninfection group).Results The serum PCT levels were(12.3±11.6),(0.26±0.25)and(0.09±0.07)μg/L,and hs-CRP levels were(22.5±20.1),(3.21±3.06)and(0.85±0.33)mg/L respectively in sepsis group,infection group and noninfection group,showing significant differences among three groups(P<0.05).The sensibilities of PCT and hsCRP were 84.8% and 87.9%,and the specificities of PCT and hs-CRP were 96.2% and 86.1%.Conclusions The detection of PCT and hs-CRP is helpful to the diagnosis of early neonatal sepsis.更多还原