【摘要】 目的探讨2型糖尿病患者糖化血清白蛋白(glycated albumin,GA)与糖尿病肾病的相关性。方法 482例2型糖尿病患者根据尿白蛋白水平分为正常白蛋白尿组(正常组)94例,微量白蛋白尿组(微量组)171例及大量白蛋白尿组(大量组)217例,检测3组血压、三酰甘油、胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、血糖、GA,并与同期50例健康体检者(对照组)进行比较。结果大量组舒张压、三酰甘油、胆固醇、低密度脂蛋白胆固醇、糖化血红蛋白、GA、血糖均高于正常组(P<0.05)。大量组、微量组和正常组GA分别为(33.0±9.3)%、(18.9±3.1)%、(14.1±2.2)%,均高于对照组((1.89±1.50)%)(F=311.511,P<0.01);糖尿病肾病的严重程度与GA水平呈正相关(r=0.885,P<0.01)。logistic回归分析显示,GA是影响糖尿病肾病发病及病情严重程度的危险因素,多因素调整后OR=2.97,95%CI:2.228~3.959。结论 GA在糖尿病肾病发病中起重要作用,并与糖尿病肾病的分期密切相关。更多还原

【Abstract】 Objective To investigate the relationship between glycated albumin(GA)level and diabetic nephropathy in patients with type 2diabetes mellitus(T2DM).Methods A total of 482patients with T2DM were divided into normoalbuminuria(NAU)group(n=94),microalbuminuria(MAU)group(n=171)and macroalbuminuria(CAU)group(n=217)according to the different albuminuria levels.The blood pressure,triacylglycerol,total cholesterol,low density lipoprotein-cholesterol,glycosylated hemoglobin,plasma glucose and GA were detected and compared with other50healthy volunteers(control group).Results The diastolic blood pressure,triacylglycerol,total cholesterol,low density lipoprotein-cholesterol,glycosylated hemoglobin,GA and plasma glucose were higher in CAU group than those in NAU group(P<0.05).GA levels in CAU,MAU and NAU groups were(33.0±9.3)%,(18.9±3.1)%and(14.1±2.2)%,significantly higher than GA level in control group((1.9±1.5)%)(F=311.511,P<0.01).The severity of diabetic nephropathy was correlated with GA level(r=0.885,P<0.01).Logisticregression showed that GA was a risk factor for the development and progression of DN after adjustment for multi-factors(OR=2.97,95%CI:2.228to3.959).Conclusions GA plays an important role in the pathogenesis of diabetic nephropathy,and is closely correlated with the phases of diabetic nephropathy.更多还原