【摘要】 目的:研究乌司他丁对外伤失血性休克的临床疗效及血清肿瘤坏死因子-α的影响。方法:选取本院收治的外伤失血性休克患者80例作为研究对象,对照组给予常规急救措施,观察组给予常规急救措施联合乌司他丁治疗,比较两组血压、肝肾功能及炎症因子水平。结果:治疗后15、30、45、60min时,观察组收缩压和舒张压均高于对照组;观察组1、2d时肝功能指标、肾功能指标、治疗后1d炎症因子均明显低于对照组,差异具有统计学意义(P<0.05)。结论:乌司他丁治疗有助于生命体征的恢复、降低炎症因子水平、控制炎症反应,是外伤失血性休克治疗的理想方法。更多还原

【Abstract】 Objective:To investigate the clinical therapeutic effects of ulinastatin on traumatic hemorrhagic shock and its influence on serum tumor necrosis factor-a.Methods:A total of 80 patients with traumatic hemorrhagic shock were enrolled and divided into observation group and control group.The control group was given routine emergency treatment combined with ulinastatin and control group was given routine emergency treatment.Blood pressure,liver function,renal function and inflammatory factor levels were compared between two groups.Results:15min,30 min,45min,60 min after treatment,systolic blood pressure and diastolic blood pressure of observation group were both higher than those of control group.Index of liver function(ALT,AST and LDH),renal function index(SCr,BUN)on 1st and 2nd of treatment,and inflammatory cytokines(CRP,TNF-α,IL-6)on the 1st day after treatment were all significantly lower than those of control group(P<0.05).Conclusion:Ulinastatin can promote the recovery of vital signs,decrease the level of inflammatory factors,control inflammation reaction,and is an ideal treatment for traumatic hemorrhagic shock.更多还原