【摘要】 目的:探讨SOX2及Wnt/β-catenin信号通路与肺癌发生的关系。方法:收集86例肺癌组织和20例正常肺组织标本,应用免疫组化法检测SOX2、β-catenin蛋白的表达,分析SOX2、β-catenin蛋白在肺癌组织中表达的关联性。结果:SOX2在肺癌组织中的阳性表达率为95.4%,在正常肺组织中无表达;β-catenin在肺癌组织中的阳性表达率为75.6%,在正常肺组织中为30.0%;肺癌组织中两种蛋白的阳性表达率均高于正常肺组织(P<0.001)。二者在肺癌组织中的表达无关联(rP=0.109,P=0.978)。结论:SOX2和Wnt/β-catenin信号通路在肺癌的发生过程中发挥了重要作用。更多还原

【Abstract】 Aim:To investigate the expressions of stem cell factors SOX2 and β-catenin in lung cancer tissue. Methods :A total of 86 cases of lung cancer tissue and 20 cases of normal lung tissue were collected and used to detect the expressions of SOX2 and β-catenin by immunohistochemistry analysis. The correlation between SOX2 and β-catenin expressions in lung cancer tissue was analyzed. Results:The positive expression rates of SOX2 and β-catenin were 95. 4% and 75. 6% in lung cancer tissue,significantly higher than those( 0. 0% and 30. 0%) in normal lung tissue( P < 0. 001). There was no positive correlation between SOX2 and β-catenin expressions in lung cancer tissue( r P = 0. 109,P = 0. 978). Conclusion:SOX2 and Wnt/β-catenin pathway may play important roles in occurrence of lung cancer.更多还原