【摘要】 目的:了解河南省成人乙型病毒性肝炎(简称乙肝)流行现状,分析成人乙肝病毒(HBV)感染的血清流行病学变化趋势。方法:采用分层整群随机抽样方法抽取样本,对河南省30个县区15~74岁人群共17 986人进行了问卷调查和采血,采用ELISA方法对血样进行HBV血清学指标的检验,对于阳性标本采用另一种试剂盒复检,复检结果与初检不一致的用全自动微粒子酶免分析仪确定。对HBsAg检测结果为阳性的对象按照1∶3选择对照,分析HBV感染的风险因素。结果:河南省2012年成人的HBV感染率为45.29%,HBsAg阳性率为3.99%,抗-HBc阳性率为44.95%,抗-HBs阳性率为45.16%;其中15~岁年龄组HBsAg阳性率最低,为3.04%,55~74岁年龄组HBsAg阳性率最高,为4.97%;15~岁年龄组抗-HBs阳性率最高,为46.08%,55~74岁年龄组抗-HBs阳性率最低,为10.15%。不同的血清学指标与年龄呈现不同的曲线关系,HBsAg阳性率和抗-HBc阳性率随年龄升高而升高。多因素分析结果表明,家庭成员长期一起生活是主要的传播方式。结论:河南省成人HBV感染率有缓慢下降趋势。更多还原

【Abstract】 Aim:To investigate and analyze seroepidemiology of HBV in Henan adult population. Methods:The cluster random sampling was used. A total of 17 986 people aged 15 ~ 74 years who lived in thirty districts or counties of Henan were investigated. The ELISA was used for detecting the HBV serological markers. The positive samples were detected repeatedly by the other kits produced by different company. The case-control was selected 1∶3 to analyze the risk factors. Results:The infection ratio of HBV in adults of Henan was 45. 29%,the positive ratio of HBsAg was 3. 99%,the positive ratio of anti-HBc was 44. 95%,and the positive ratio of anti-HBs was 45. 16%. 15 ~ years group had the lowest positive ratio of HBsAg( 3. 04%) and the highest anti-HBs positive ratio( 46. 08%). 55 ~ 74 years group had the highest positive ratio of HBsAg( 4. 97%) and the lowest anti-HBs positive ratio( 10. 15%). There were different linear relation between the different serological index and age. The multiple-factor analysis results showed that the infection happened in family was the main risk factor. Conclusion:The HBV infection rate of adults in Henan was declining little by little.更多还原