【摘要】 目的探讨动脉粥样硬化型脑梗死患者同型半胱氨酸(Hcy)水平及其与预后的关系。方法采用前瞻性队列研究方法连续登记2010-01—2013-05入住我科脑梗死患者,并进行TOAST分型,其中Ⅰ型入选为研究组,对照组为同期健康体检者,均行Hcy水平检测,对脑梗死患者入院时及3个月后采用美国国立卫生院神经功能缺损评分量表(NIHSS)及改良Rankin量表评分(MRS)进行评价,并对数据进行分析。结果研究组Hcy水平较对照组明显升高,差异有统计学意义(P<0.05);研究组Hcy水平与入院时NIHSS、MRS评分无相关性(P>0.05),但与3个月后NIHSS和MRS改善程度相关(P<0.05),>15.57μmol/L患者预后差。结论血浆Hcy水平增高可能是脑梗死的危险因素,可反映预后转归情况。更多还原

【Abstract】 Objective To investigate the level of homocysteine(Hcy)and the relationship between homocysteine and prognosis in atherosclerotic patients with cerebral infarction.Methods Cerebral infarction patients in our hospital from January2010 to May 2013 were classified according to TOAST,and then the TOAST-Ⅰpatients were considered as the research group and the healthy people at the same time were considered as the control group.The Hcy levels of two groups on admission and3 months after treatment were evaluated by the NIHSS and MRS scores.Results The Hcy level of research group was higher than that of control group;the Hcy level of research group was related with or without the NIHSS and MRS scores(on admission or 3months after treatment).The Hcy>15.57μmol/l group had a worse prognosis.Conclusion Increased Hcy level may be the risk factors for patients with cerebral infarction,which can reflect the patient’s prognosis.更多还原