【摘要】 目的探讨联合评分方法对短暂性脑缺血发作(transient is chemic attack,TIA)后早期卒中风险进行评估的效能。方法收集120例TIA患者,通过头DWI明确有无新鲜梗死。入院后对患者进行ABCD2评分,检测患者血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、血浆纤维蛋白原(fibrinogen,FIB)的含量。在ABCD2评分基础上,结合血清hs-CRP、FIB结果形成联合评分,对比分析TIA后1周内ABCD2评分与联合评分两种方法的评估效能。结果 120例TIA患者中,39例(32.5%)在发病1周内发生脑梗死。ABCD2评分与联合评分两种方法结果一致,脑梗死发病率由高到低顺序为:高危>中危>低危。联合评分低、中危组人数减少,高危组人数增加。与ABCD2评分比较,联合评分低、中危组脑梗死发病率降低,高危组脑梗死发病率升高。联合评分的ROC曲线下面积显著大于ABCD2评分(P<0.001)。结论结合临床生化检验结果的联合评分效能高于单纯的ABCD2评分,联合评分能更好预测高危人群TIA后早期进展为脑梗死的风险,可用于临床指导TIA危险分层和治疗。更多还原

【Abstract】 Objective To investigate the application of composite scoring system in evaluating the early stroke risk after transient ischemic attack risk(TIA).Methods 120 patients with TIA were evaluated by the ABCD2 score,and then the hypersensitive C-reactive protein(hs-CRP)and fibrinogen(FIB)in serum were measured.The ABCD2 score combined with the results of hs-CRP and FIB formed the composite scoring system,and then the area under the receiver operating characteristic(ROC)curve were compared between the ABCD2 score and the composite scoring system.Results The area under the ROC curve of composite scoring system was significantly larger than that of ABCD2.Conclusion The composite scoring system criteria can effectively predict the early occurrence of cerebral infarction after TIA,and guide the aggressive diagnostic protocols and therapy of TIA.更多还原