【摘要】 目的:对用活化血浆凝固时间(APCT)评价血小板输注疗效的价值进行研究。方法:在2011年1月至12月于我院住院治疗的血小板计数(PLT)均<50×109L-1的血液病患者中,出血的患者34例为观察组,不出血34例为对照组。对两组患者静脉采血测PLT、APCT;再对观察组和对照组中PLT<10×109L-1的患者给予血小板输注,抗凝后测其APCT、PLT,并计算校正血小板增高指数(CCI)和实际血小板回收率(PPR),比较对血小板输注疗效的评价。结果:有3例未出血患者要进行输注,出血组患者PLT≤20×109L-1和PLT≤10×109L-1的APCT两者相比差异无统计学意义(P>0.05),两组进行血小板输注前APCT和PLT的比较均具有统计学差异(P<0.05);与血小板输注前相比,输注后APCT明显缩短,差异具有显著性统计学意义(P<0.01);观察组中29名患者输注有效,且24h后APCT都小于80s,有2名患者的CCI和5名患者的PPR符合血小板输注无效标准,另外5名患者的输注无效,24h后的APCT都大于80s,而CCI、PPR只有2名符合血小板输注无效标准。结论:APCT可以较好的折射血小板数量和质量的变化,也可以较全面的评较血小板的输注疗效。更多还原

【Abstract】 Objective: To study the value of activated plasma coagulation time( APCT) on evaluation of platelet transfusion.Method: Patients with blood disease and blood platelets count( PLT) was less than 50×109L-1in our hospital from January to December 2011 were selected,in which 34 hemorrhage patients were selected as the observation group,and 34 patients without hemorrhage were selected as the control group.PLT,APCT of two groups were detected,platelet transfusion was adopted in patients whose PLT was less than10×109L-1,detected APCT,PLT after anticoagulation,then calculated corrected count increment( CCI) and practical platelet recovery( PPR).Result: There were three patients adopted platelet transfusion,difference of PLT≤20×109L-1and PLT≤10×109L-1in hemorrhage patients had no statistical significance( p>0.05),APCT had shortened compared to that before platelet transfusion,difference was statistically signficant( p<0.01); in observation group platelet transfusion was effective in 29 patients,APCT was less than 80s after 24h,CCI of 2 patients and PPR of 5 patients met the invalid standard of platelet transfusion,in addition,platelet transfusion of 5 patients was invalid,APCT was more than 80s after 24h,only 2 patients’ CCI and PPR met the invalid standard of platelet transfusion.Conclusion: ACT not only can show the number and quality changes of blood platelet well,but also evaluate the efficacy of platelet transfusion more comprehensively.更多还原