【摘要】 曲酸、靛红和氰基乙酸甲酯在碳酸氢钠催化下经三组分缩合反应合成了一系列新型的3,3’-螺环氧化吲哚曲酸衍生物,其结构经1H NMR,13C NMR和ESI-HR-MS表征。在最佳反应条件[甲醇为溶剂,1 eq.碳酸氢钠为催化剂,于室温反应24 h]下,收率最高为86%。更多还原

【Abstract】 A series of novel spiro[4H-pyran-3,3’-oxindoles]kojic acid derivatives were synthesized by three-component condensation of kojic acid,methyl cyanoacetate and isatins in the presence of sodium bicarbonate.The structures were characterized by1H NMR,13C NMR and ESI-HR-MS.Under the optimum reaction conditions at rt for 24 h using methanol as the solvent and NaHCO3(1 eq.) as the catalyst,the yield was up to 86%.更多还原