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2,2-二丙基-β-丙氨酸的合成
Synthesis of 2,2-Dipropyl-β-alanine
【摘要】 以氰基乙酸乙酯为起始原料,在强碱作用下与溴丙烷经两次烷基化反应制得2-氰基-2-丙基-戊酸乙酯(3);3中氰基经镍催化还原为氨基得2-氨甲基-2-丙基-戊酸乙酯(4);4经水解反应合成了2,2-二丙基-β-丙氨酸,总收率37.4%,其结构经1H NMR确证。
【Abstract】 Ethyl 2-cyano-2-propylvalerate( 3) was obtained from ethyl cyanoacetate by two-step alkylation. Ethyl 2-amino-2-propylvalerate( 4) was prepared by catalytic reduction of 3 with Raney Ni. 2,2-Dipropyl-β-alanine was synthesized by hydrolysis of 4. The total yield was 37. 4%. The structures were confirmed by1H NMR.
- 【文献出处】 合成化学 ,Chinese Journal of Synthetic Chemistry , 编辑部邮箱 ,2014年01期
- 【分类号】O643.32
- 【被引频次】1
- 【下载频次】111