【摘要】 目的探讨联合检测血清癌胚抗原(earcinoembryonicantigen,CEA)、糖链抗原19-9(carbohyrate antigan19-9,CA19-9)和炎症标志物C反应蛋白(C-reaction protein,CRP)对大肠癌诊断的临床应用价值。方法分别检测146例大肠癌患者、158例阑尾炎和结肠息肉患者、76例健康者CEA、CA19-9、CRP水平,并应用受试者工作特征(receive operating characteristic,ROC)曲线进行评价。结果与正常对照组比较,大肠癌组和良性炎症组血清CRP、CEA和CA19-9水平均升高,大肠癌组CRP显著低于良性炎症组,但大肠癌组CEA、CA19-9明显高于良性炎症组和正常对照组,差异有统计学意义(P<0.01))。用ROC曲线比较CEA、CA19-9和CRP区分良性炎症组和大肠癌的能力,显示CRP的诊断价值优于CEA和CA19-9。利用ROC曲线分析联合检测三者的诊断能力,其ROC曲线下面积(area under the ROC curve,AUC)为0.886。结论联合检测CEA、CA19-9和CRP可以弥补单项检测的不足,提高临床诊断的准确性,联合检测的准确性优于单项检测。更多还原

【Abstract】 Objective To assess the diagnostic value of combined detection of tumor markers carcinoembryonic antigen(CEA),carbohyrate antigen 19-9(CA19-9) and inflammatory marker C reactive protein(CRP) in colon cancer.Methods Serum levels of CEA,CA199 and CA125 were determined in 146 patients with colorectal cancer,158 patients with inflammatory bowel disease,colon polyp or acute appendicitis,and 76 healthy persons.And their accuracies and consistencies with the analysis of receive operating characteristic(ROC) and value of Kappa were evaluated.Results Compared with the control group,the serum CRP,CA19-9 and CEA in patients with colon cancer and inflammatory bowel disease were significantly increased.The levels of CEA and CA19-9 in colon cancer group were obviously higher than those of inflammatory bowel disease group and control group.ROC was used to compare the diagnostic value of CEA,CA19-9 and CRP in discriminating benign inflammatory and colon cancer groups,indicating the diagnostic value of CRP was better than that of CEA and CA19-9.The AUC of combined detection of CEA,CA19-9 and CRP was 0.886.Conclusion Combined detection of CEA,CA199 and CRP can help improve the diagnosis accuracy of colorectal cancer.The diagnostic accuracy was superior to individual item.更多还原