【摘要】 目的观察舍曲林联用多奈哌齐治疗对阿尔茨海默病伴发抑郁症状患者的疗效及认知功能。方法将符合阿尔茨海默病伴发抑郁症状诊断标准的42例患者按序号分为两组,试验组在口服多奈哌齐的基础上联用舍曲林,对照组仅口服多奈哌齐,疗程8周。用汉密尔顿抑郁量表(HAND)评定抗抑郁的疗效,用简易智力状态检查(MMSE)评定认知功能。结果试验组治疗1周末HAND-D评分与治疗前相比差异即有显著性(P<0.05);与对照组相比,试验组治疗2周末HAND评分两组差异即有非常显著性(P<0.01);试验组治疗后MMSE有提高,差异有显著性(P<0.05)。结论舍曲林治疗阿尔茨海默病伴发抑郁症状疗效明显,对认知功能有改善。更多还原

【Abstract】 OBJECTIVE To observe the effect and cognitive function of Sertraline combined with Donepezilin Alzheimer’ s disease with depressive symptoms. METHODS 42 patients of Alzheimer’ s disease with depressive symptoms that conforms to the diagnostic standard were divided into two group according to serial number. The treatment group was given Donepezil combined with Sertraline,the control group was given Donepezil only. The patients were observed for 8 weeks. Patients were evaluated by the Hamilton Depression Scale( HAND) for the efficacy of antidepressant and mini mental state examination( MMSE) for the cognitive function. RESULTS The treatment group had significant difference of HAND-D score after 1 weeks treatment( P < 0. 05). Compared with the control group,the treatment group had significant difference of HAND-D score after 2 weeks treatment( P < 0. 01). MMSE were increased significandly in the treatment group after treatment( P < 0. 05). CONCLUSION The effect of sertraline is obvious in Alzheimer’s disease with depressive symptoms. The cognitive function is improve after patients used Sertraline.更多还原