【摘要】 目的探讨血清同型半胱氨酸(Hcy)、脂蛋白(α)[Lp(α)]和胱抑素C(Cys-C)水平变化在2型糖尿病肾病(Type 2 diabetic nephropath,T2DN)诊断中的临床应用价值。方法在日立7600-020全自动生化分析仪上测定106例T2DN患者(实验组)和92例健康者(对照组)的血清Hcy、Lp(α)、Cys-C和糖化血红蛋白(HbA1c),并对测定结果进行比较分析。结果实验组患者的Hcy、Lp(α)、Cys-C和HbA1c水平显著高于对照组(P<0.05);早期糖尿病肾病组和中晚期糖尿病肾病组Hcy、Lp(α)、Cys-C和HbA1c水平均高于单纯糖尿病组(P<0.05);中晚期糖尿病肾病组Hcy、Lp(α)、Cys-C和HbA1c水平高于早期糖尿病肾病组(P<0.05)。结论血清Hcy、Lp(α)和Cys-C可作为T2DN早期肾损伤较为理想的评价指标,能为T2DN早期诊断、病情监测和疾病预后等方面提供有价值的实验依据。更多还原

【Abstract】 Objective To study the diagnostic value of serum homocysteine(Hcy),lipoprotein(α) [Lp(α)]and Cystatin C(Cys-C) testing in type 2 diabetic nephropathy(T2DN).Methods The serum levels of Hcy,Lp(α),Cys-C and glycosylated hemoglobin(HbA1c) in 106 cases of T2DN(experimental group) and 92 healthy subjects(control group) were determined by 7600-020 automatic biochemical analyzer and the results were compared.Results In the experimental group,the levels of Hcy,Lp(α),Cys-C and HbA1 cwere significantly higher than those in the control group(P<0.05);the levels of Hcy,Lp(α),Cys-C and HbA1 c in early or advanced diabetic nephropathy group were significantly higher than those in simple diabetic group(P<0.05);and the levels of Hcy,Lp(α),Cys-C and HbA1 cin advanced diabetic nephropathy group were significantly higher than those in the early diabetic nephropathy group(P<0.05).Conclusion The serum Hcy,Lp(α) and Cys-C can be regarded as optimal indexes to evaluate early renal injury in T2 DN,which can provide experimental data for monitoring and its prognosis.更多还原