【摘要】 目的探讨乳腺浸润性导管癌中c-erbB-2的表达及其与腋窝淋巴结、超声征象等的相关性。方法选取新疆自治区人民医院173例乳腺浸润性导管癌的石蜡标本,应用免疫组织化学方法检测乳腺浸润性导管癌患者乳腺原发灶及腋淋巴结转移灶中c-erbB-2的表达,分析其与超声表现、腋窝淋巴结转移状况的关系。同时取78例非癌乳腺组织作为对照。结果 c-erbB-2的表达率为32.95%,较非癌乳腺组织的c-erbB-2表达率高,差异有统计学意义(P<0.01)。乳腺浸润性导管癌组织中c-erbB-2的表达情况在腋窝是否存在淋巴结转移中不同且差异有统计学意义(P<0.05)。c-erbB-2表达率的增高在有微钙化、后方声衰减征象中均有不同程度的体现,且与对照组比较差异有统计学意义(P<0.05)。结论乳腺浸润性导管癌组织的c-erbB-2蛋白表达水平呈显著增高趋势,c-erbB-2蛋白表达与腋窝淋巴结转移正相关;微钙化、后方声衰减征象与c-erbB-2的过表达存在一定程度的关联。更多还原

【Abstract】 Objective To explore the correlation between c-erbB-2 expression and axillary lymph nodes, ultrasonographic signs of invasive ductal carcinoma. Methods Immunohistochemical technique was performed to detect the expression of oncogene c-erbB-2 in 173 cases of primary carcinoma. Analysis of its relationship with ultrasonography, axillary lymph node status. 78 cases of non-cancerous breast tissue were taken as a control. Results C-erbB-2 expression was 32.95%, and the c-erbB-2 expression rate was higher than that of noncancerous breast tissue(P<0.01). the expression rate of C-erbB-2 in cases increased in the presense of Microcalcification and acoustic attenuation of poste, which was significant different form controls. Conclusion There is a significantly increased trend of c-erbB-2 protein expression levels of invasive ductal carcinoma. c-erbB-2 protein expression correlates with lymph node metastasis. There is some correlation between micro calcifications, posterior acoustic attenuation signs and c-erbB-2 overexpression.更多还原