【摘要】 目的探讨基质金属蛋白酶(matrix metalloproteinase,MMPs)及其抑制剂(TIMPs)和转化生长因子-β1(TGF-β1)在中鼻甲息肉的表达情况。方法采用酶联免疫吸附试验(ELISA)检测30例中鼻息肉与40例中鼻甲黏膜组织中的MMP-1、TIMP-1以及TGF-β1的表达量,并对其在不同组织中表达情况的差异性进行对比分析。结果中鼻甲息肉组织中MMP-1、TIMP-1以及TGF-β1的阳性表达率分别为100.00%、73.33%及100.00%,中鼻甲黏膜组织中阳性表达率分别为0%、75.00%及25.00%,两组MMP-1及TGF-β1阳性表达率相比,差异均具有显著的统计学意义(P<0.01),但是两组TIMP-1阳性表达率相比,差异无统计学意义(P>0.05);经Spearman等级相关分析,中鼻甲息肉中MMP-1与TGF-β1阳性表达间存在正相关性(r=0.721,P<0.01),但TIMP-1与TGF-β1阳性表达间的差异不存在相关性(r=-0.049,P>0.05)。结论 MMP-1及TGF-β1在中鼻甲息肉组织中有较强的表达,可作为中鼻甲息肉发生与发展的重要指示物。更多还原

【Abstract】 Objective To investigate the matrix metalloproteinases(MMPs)and their inhibitors(TIMPs)and transforming growth factor-β1(TGF-β1)expression in middle turbinate nasal polyps. Methods Using enzyme-linked immunosorbent assay(ELISA),30cases and 40cases of nasal turbinate mucosa of MMP-1,TIMP-1and TGF-β1expression were detected,and its expression in different tissues differences were analyzed.Results The middle turbinate nasal polyps MMP-1,TIMP-1and TGF-β1positive expression rate was 100.00%,73.33%and 100.00%,middle turbinate mucosa positive expression rates were 0%,75.00% and 25.00 %,respectively,MMP-1and TGF-β1expression rate,the differences were significant statistical significance(P<0.01),but the two sets of TIMP-1 expression rate,the difference was not statistically significant(P>0.05).The Spearman rank correlation analysis,MMP-1in middle turbinate nasal polyps and TGF-β1expression positive correlation exists between(r=0.721,P<0.01),but TIMP-1and TGF-β1expression between the difference was not correlated(r=-0.049,P>0.05).Conclusion MMP-1and TGF-β1in middle turbinate nasal polyps have a stronger expression in middle turbinate nasal polyps and can be used as an important indicator of development.更多还原