【摘要】 目的:探讨体外受精-胚胎移植(IVF-ET)卵巢过度刺激综合征(OHSS)高危患者行全胚胎冻存对预防中重度OHSS的临床应用价值。方法:分析2008年5月—2012年12月在高海拔地区行IVF助孕患者胚胎移植日OHSS高危患者142例,分为两组:研究组行全胚胎冻存及行首次冻融胚胎移植(FET)患者68例;对照组行新鲜胚胎移植患者74例;对研究组与对照组间的各实验室、临床资料、中重度OHSS发生率、临床结局进行比较分析。结果:研究组与对照组间的各实验室、临床一般资料比较,差异无显著性(P>0.05),两组间中重度OHSS发生率差异有显著性(P<0.05);两组间移植胚胎数、移植优胚率、妊娠率差异均无显著性(P>0.05);两组间移植日子宫内膜厚度、着床率、流产率差异均有显著性(P<0.05)。结论:在高海拔地区对胚胎移植日OHSS高危患者取消本周期新鲜胚胎移植行全胚胎冻存,择期冻融胚胎移植,可有效避免妊娠后晚发中重度OHSS的发生,防止早发OHSS的进一步恶化,减少早发中重度OHSS的发生,减轻患者的症状及减少血栓形成等严重并发症;且与轻度OHSS新鲜胚胎移植相比对轻度OHSS患者行全胚胎冻存后冷冻胚胎移植有着良好的临床结局。更多还原

【Abstract】 Objective: To explore the clinical value of total embryos frozen for preventing patients with high risk of ovarian hyper- stimulation syndrome( OHSS) caused by in vitro fertilization and embryo transplantation( IVF-ET). Methods: A retrospective analysis was made in 142 patients at high altitudes,these patients were at high risk of ovarian hyper- stimulation syndrome in the course of IVF- ET day from May 2008 to December 2012. They were divided into two groups: trial group and control group,68 patients in trial group and 74 patients in control group.Based on the laboratory data,clinical data,moderately severe OHSS incidence and the clinical outcome,a comparative analysis between the two groups was carried out. Results: There was no significant difference( P > 0. 05) concerning the laboratory data and clinical general information of both groups. But the incidence of the moderately severe OHSS showed significant difference( P < 0. 05) between the two groups. There was significant difference( P <0. 05) in the transplant endometrial thickness,implantation rate and abortion rate between the two groups. Conclusion: It is effective for total embryos frozen to prevent OHSS at high altitudes for the patients who is at high risk of OHSS in IVF- ET. This treatment can avoid severe OHSS of pregnancy,relieve symptoms of patients,reduce thrombosis,etc; and shows a good clinical outcome.更多还原