【摘要】 目的探讨乳脂肪球表皮生长因子(MFG-E8)水平变化对诊断乳腺浸润性导管癌的价值及相关性。方法经病理组织学确诊的浸润性乳腺癌患者38例为观察组,40例体检正常妇女作为对照组,比较两组血清MFG-E8、CD68、血管内皮生长因子(VEGF)、细胞增殖相关蛋白(Ki67)、CA15-3、CEA的水平。结果观察组MFG-E8、CD68、VEGF、CA15-3、CEA的表达水平均显著高于对照组(P<0.05),观察组的Ki67表达水平显著低于对照组(P<0.05);观察组MFG-E8表达水平与CA15-3、CEA表达水平呈正相关(P<0.001)。结论临床检测MFG-E8水平对乳腺浸润性导管癌具有较高的诊断价值。更多还原

【Abstract】 Objective To evaluate milk fat globule epidermal growth factor 8( MFG-E8) in the diagnosis of breast invasive ductal carcinoma,and to investigate the correlation between MFG-E8 level and breast invasive ductal carcinoma. Methods Thirty-eight cases of breast invasive ductal carcinoma confirmed by histopathology were in the observation group,40 normal women were in the control group. The levels of serum MFG-E8,CD68,vascular endothelial growth factor( VEGF),cell proliferation related protein( Ki67),CA15-3 and CEA were compared between two groups.Results The expression levels of MFG-E8,CD68,VEGF,CA15-3 and CEA in the observation group were significantly higher than those in the control group( P < 0. 05),Ki67 expression level in the observation group was significantly lower than that in the control group( P < 0. 05). MFG-E8 expression level positively correlated with CA15-3,CEA expression levels in the observation group( P < 0. 001). Conclusion MFG-E8 level is valuable in the diagnosis of breast invasive ductal carcinoma.更多还原