【摘要】 目的比较体外受精-胚胎移植(IVF-ET)中促性腺激素释放激素(GnRH)拮抗剂方案、与GnRH激动剂长方案治疗多囊卵巢综合征(PCOS)患者的助孕结局。方法行IVF-ET的PCOS不孕患者118例,其中研究组48例采用GnRH拮抗剂方案,对照组70例采用GnRH激动剂长方案,比较分析两组的助孕结局。结果两组的平均获卵数、卵母细胞成熟率、受精率、卵裂率、优质胚胎率、胚胎种植率、临床妊娠率、卵泡液的IL-1β浓度比较差异均无统计学意义(P>0.05);研究组的促性腺激素(Gn)使用时间和Gn用量明显少于对照组(P<0.05),卵巢过度刺激综合征(OHSS)发生率和周期取消率低于对照组(P<0.05)。结论 GnRH拮抗剂方案治疗PCOS不孕症能降低OHSS发生风险、减少周期取消率及减少Gn使用时间及其用量,而平均获卵数、受精率、卵裂率、优质胚胎率、临床妊娠率、种植率均不受影响。更多还原

【Abstract】 Objective To compare the treatment outcomes between gonadotropin-releasing hormone( GnRH)antagonist protocol and GnRH agonist long protocol applied to polycystic ovary syndrome( PCOS) patients undergoing in vitro fertilization and embryo transfer( IVF-ET). Methods One hundred and eighteen cases of PCOS patients undergoing IVF-ET were divided randomly into study groupcontrol group. Forty-eight patients in study group were subjected to a protocol of using GnRH antagonist. Seventy patients in control group were subjected to a long protocol of using GnRH agonist. The clinical outcomes of two groups were compared. Results There were no significant differences in the average number of oocyte,the mature rate of oocytes,the fertilization rate,the cleavage rate,the rate of high-quality embryos,the implantation rate,the pregnancy rate and the concentration of IL-1β in follicular fluid between two groups( P > 0. 05).The time and doses of administration of gonadotropins in the study group were obviously less than those in the control group( P <0.05).The incidence and cycle cancellation rate of ovarian hyperstimulation syndrome( OHSS) in the study group were significantly lower than those in the control group( P <0. 05). Conclusion The GnRH antagonist protocol could decrease the incidence,cycle cancellation rate of OHSS as well as reduce the time and doses of administration of gonadotropins.However,the number of oocyte,the fertilization rate,the cleavage rates,the rate of high-quality embryos,the pregnancy rate and the implantation rate are not affected.更多还原