【摘要】 目的系统评价国内早期乳腺癌保乳手术治疗(BCT)与改良根治术(MRM)对照的远期疗效。方法检索2006~2013年收集已发表的关于早期乳腺癌保乳治疗与改良根治术对照试验的国内文献,针对结果进行统计学综合(Meta)分析。采用优势比(OR)及95%置信区间(95%CI)描述效应量。以3年生存率、局部复发率、远处转移率进行综合评价早期乳腺癌手术现状。结果 27篇中文文献符合纳入标准,包括1136例保乳手术患者和1325例改良根治术手术患者;(1)3年生存率指标对比,差异无统计学意义(P>0.05),提示保乳组手术与改良根治术组3年无病生存率无差别;(2)3年局部复发率比较,差异无统计学意义(P>0.05),即认为保乳组3年局部复发率与改良根治术组相当;(3)对3年肿瘤远处转移指标进行分析,差异无统计学意义(P>0.05),提示保乳组与改良根治术组在3年肿瘤远处转移率上无明显区别。结论保乳手术与改良根治术具有相同的远期疗效,保乳手术具有创伤性小、术后恢复快,美观,有效提高生存质量,可作为早期乳腺癌治疗的首选。更多还原

【Abstract】 Objective To evaluate the early breast cancer conserving surgery(BCT) and modified radical mastectomy(MRM) were long-term efficacy of domestic. Methods To retrieve the 2006-2013 collection has been published on early breast cancer conserving therapy and modified radical mastectomy controlled trials in domestic literature,and results were statistically for comprehensive(Meta) analysis. Using odds ratios(OR) and 95% confidence intervals(95%CI) describe effect size.just in Three-year survival rate of local recurrence,distant metastasis of a comprehensive evaluation of early breast cancer surgery status cases. Results 27 Chinese literature to be included in the standard,including 1136 cases of breast-conserving surgery patients and 1325 cases of modified radical mastectomy surgery;(1)three-year survival rate index contrast,the difference was not statistically significant(P > 0.05), prompt breast-conserving surgery group with modified radical mastectomy group of three years disease-free survival undifferentiated;(2)three-year local recurrence rate,the difference was not statistically significant(P > 0.05),namely that the three-year local recurrence of breast-conserving group of rate considerably modified radical mastectomy group;(3)three-year distant metastasis indicators to analyze the difference was not statistically significant(P > 0.05),prompt breast conserving group and modified radical mastectomy group on a three-year distant metastasis rate was no significant difference. Conclusion breast-conserving surgery and modified radical mastectomy have the same efficacy of long-term,breast-conserving surgery with less trauma of small, rapid postoperative recovery,beautiful,effectively improve the quality of life,can be used as the treatment of choice for early breast cancer.更多还原