【摘要】 【目的】为获得高效的抗氧化先导化合物,对红树白骨壤(Avicennia marina)果实中化学成分进行研究。【方法】采用柱色谱和高效液相色谱及细胞定量分析方法,对白骨壤果实中抗氧化活性成分进行研究,并运用色谱分析和文献对照方法,鉴定其化学结构。【结果】从白骨壤果实中分离鉴定了4个具有抗氧化活性的单体化合物,分别为tamarixetin-3-O-β-D-glucopyranoside(1)、3,4-dihydroxyphenethylalcohol-6-O-caffeoyl-β-D-glucoside(2)、类叶升麻苷(3)、焦地黄苯乙醇甙C(4)。化合物1~4的EC50值分别为(16.0±0.98)μM,(18.5±1.47)μM,(9.5±1.09)μM和(12.0±0.89)μM。【结论】红树白骨壤果实中存在着具有强抗氧化活性成分(1~4),且上述活性成份均为首次从该物种中分离获得。更多还原

【Abstract】 【Objective】In order to obtain strong antioxidant compounds,the fruits of mangrove Avicennia marina were investigated.【Methods】The antioxidative constituents were isolated and analyzed by column chromatograph,HPLC and cell quantiative analysis.The structure of the constituents was identified by chromatograph analysis results and previous paper.【Results】The fruits of mangrove Avicennia marinacontains one flavonoid glycoside,tamarixetin-3-β-D-glucopyranoside(1),and three known phenylethyl glycosides,3,4-dihydroxyphenethylalcohol-6-O-caffeoyl-β-D-glucoside(2),acteoside(3)and jionoside C(4).The EC50 values of compounds 1~4were(16.0±0.98)μM,(18.5±1.47)μM,(9.5±1.09)μM,and(12.0±0.89)μM,respectively.【Conclusion】The strong antioxidant compounds were obtained from the fruits of Avicennia marina,and these compounds were obtained from the fruits of this species for the first time.更多还原