Effect of temperature on noninvasive blood glucose monitoring in vivo using optical coherence tomography

【摘要】 Noninvasive glucose monitoring(NIGM) techniques based on optical coherence tomography(OCT) are affected by several perturbing factors, including variation of tissue temperature. We first design a temperature control module integrated with an optical scanning probe to precisely control the temperature of skin tissues. We investigate the influence of temperature on NIGM with OCT by correlation analysis at different depths of in vivo human skin. On average, the relative changes in attenuation coefficient( μt) per 1 °C of temperature lead to 0.30 ± 0.097 mmol/L prediction error of blood glucose concentration. For NIGM measurement methods using optical properties of the tissues, this effect can be taken into account.更多还原

【Abstract】 Noninvasive glucose monitoring(NIGM) techniques based on optical coherence tomography(OCT) are affected by several perturbing factors, including variation of tissue temperature. We first design a temperature control module integrated with an optical scanning probe to precisely control the temperature of skin tissues. We investigate the influence of temperature on NIGM with OCT by correlation analysis at different depths of in vivo human skin. On average, the relative changes in attenuation coefficient( μt) per 1 °C of temperature lead to 0.30 ± 0.097 mmol/L prediction error of blood glucose concentration. For NIGM measurement methods using optical properties of the tissues, this effect can be taken into account.更多还原