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2001—2013年邯郸市他汀类药物不良反应分析

Analysis on adverse drug reaction induced by statins in Handan City from 2001 to 2013

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【作者】 汪卫东李炜刘新平王朝宗魏亚超王乐

【Author】 WANG Wei-dong;LI Wei;LIU Xin-ping;WANG Chao-zong;WEI Ya-chao;WANG Le;Department of Pharmacy, Handan Central Hospital;Department of Neurology, Handan Central Hospital;

【机构】 邯郸市中心医院药学部邯郸市中心医院神经内科

【摘要】 目的了解邯郸市各医院使用的他汀类药物不良反应(ADR)发生情况,为临床合理用药提供依据。方法对邯郸市药品不良反应监测机构上报的2001—2013年他汀类药物不良反应登记资料进行回顾性统计分析。结果 ADR累及多个系统–器官,主要包括肝胆、胃肠、肌肉骨骼及神经系统,其他系统相对少见。严重不良反应以肝损害最常见;不同他汀类ADR有所差异,辛伐他汀主要累及肌肉骨骼、胃肠系统和肝胆系统,阿托伐他汀主要累及肝胆和神经系统,氟伐他汀主要累及胃肠系统。结论目前在临床上应用的他汀类药物在常规剂量范围内均有ADR发生,应规范降脂用药剂量和时限,减少不良反应发生。

【Abstract】 Objective To analyze the adverse drug reaction(ADR) induced by statins in Handan City, and to provide the reference for clinical rational drug usage. Methods ADRs of statins reported by Handan ADR monitoring agencies from 2001 to 2013 were retrospectively analyzed. Results ADRs involved multiple system organs including hepatobiliary system, gastrointestinal system, muscles, bones, and nervous system, while the other systems were relatively uncommon. The serious ADRs frequently involved liver dysfunction. Different kinds of statins could induce different ADR. Simvastatin mainly involved musculoskeletal, gastrointestinal, and hepatobiliary systems, and at the same time, atorvastatin mainly involved the hepatobiliary and nervous systems. Fluorine mainly affected the gastrointestinal system. Conclusion At present, ADR can occur in all statins at regular dosage range in the clinical application, and lipid-lowering drugs should be strictly regulated by dosage and time-limit, so as to reduce the incidence of ADR.

  • 【文献出处】 现代药物与临床 ,Drugs & Clinic , 编辑部邮箱 ,2014年05期
  • 【分类号】R972
  • 【被引频次】17
  • 【下载频次】218
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