【摘要】 胆碱能抗炎通路通过刺激外周迷走神经或应用中枢性毒蕈碱受体激动剂等,对损伤、病原体或组织缺血所致炎症反应发挥免疫调节作用。与体液抗炎通路相比,胆碱能抗炎通路反应时间非常短,它能够快速而直接地调节全身性炎症反应,抑制生物毒素的致死效应。本文对胆碱能抗炎通路的研究起源和构成,迷走神经与脾、炎性反射的关系进行综述。更多还原

【Abstract】 The cholinergic anti-infla mmatory pathway regulates the inflammation response to injury,pathogens,tissue ischemia et al,by stimulating the peripheral vagus or centrally acting muscarinic agonists. It can regulate the systemic inflammation rapidly and directly,and inhibit the lethal effect of biotoxins(e.g,lipopolysaccharide). Based on the recent advancements,the historical origins and constitution of the cholinergic anti-inflammatory pathway,the connection between vagus and spleen,and the relationship with the inflammatory reflex are summarized.更多还原