【摘要】 目的研究儿童低淋巴细胞血症患者的细胞因子水平。方法 56例3~14岁低淋巴细胞血症儿童作为患者组,20例健康体检儿童作为对照组。用酶联免疫吸附试验(ELISA)测定血清细胞因子白细胞介素(IL)-1、IL-6、IL-8和肿瘤坏死因子(TNF)-α水平,AU640全自动生化分析仪测定高敏C反应蛋白(hs-CRP)水平。结果患者组的IL-1、IL-6、IL-8和TNF-α的水平分别为(0.096±0.012)ng/mL、(0.118±0.026)ng/mL、(0.388±0.069)ng/mL和(1.256±0.245)ng/mL,与对照组相比差异无统计学意义(P>0.05);患者组CRP水平为(5.7±2.8)mg/L,对照组hs-CRP水平为(4.8±2.6)mg/L,两者比较差异无统计学意义(P>0.05)。结论儿童低淋巴细胞血症患者的炎症因子并不增高,可能与其他因素有关,积极使用中药治疗有利于疾病的恢复。更多还原

【Abstract】 Objective To investigate the levels of inflammatory cytokines in children with low absolute lymphocyte count(ALC).Methods 56 patients with low ALC as the patients group and 20 children with healthy physical examination as the control group were enrolled.Several inflammatory cytokines,namely IL-1,IL-6,IL-8and TNF-βwere measured with enzyme linked immunosorbent assay(ELISA)kits.High sensitive C reactive protein(Hs-CRP)was measured by the immunoturbidimetry(ITM)kit with the automatic biochemical analyzer.Results The concentrations of IL-1,IL-6,IL-8and TNF-βin the patients were(0.096±0.012)ng/mL,(0.118±0.026)ng/mL,(0.388±0.069)ng/mL and(1.256±0.245)ng/mL respectively,which had no statistical differences as compared with the control group(P>0.05);the concentration of HsCRP in the patients group was(5.7±2.8)mg/L,while which in the control group was(4.8±2.6)mg/L,showing no statistically significant difference between them(P>0.05).Conclusion The levels of the cytokines in low ALC patients are not increased,which may be related with the other factors.Actively using traditional Chinese medicine treatment is beneficial to the recovery of disease.更多还原