【摘要】 目的探讨急性缺血性脑卒中患者血清超敏C反应蛋白(hs-CRP)的水平变化及其临床意义。方法采用高灵敏度的全自动散射比浊免疫分析仪——BNⅡ检测急性缺血性脑卒中患者64例及同期来医院体检的健康体检者32例的血清hs-CRP的水平变化,回顾性分析急性缺血性脑卒中患者的病例资料。结果急性缺血性脑卒中组hs-CRP阳性率是53.3%,体检组的hs-CRP的阳性率为9%,二者具有显著性差异(P<0.05);急性缺血性脑卒中组hs-CRP的整体水平不符合正态分布,中位数是4.26mg/L,体检组的hs-CRP的平均水平(0.99±0.72)mg/L,二者具有显著性差异(P<0.05);急性缺血性脑卒中男性组hsCRP平均水平是(5.03±1.51)mg/L,急性缺血性脑卒中女性组hs-CRP平均水平是(2.79±1.09)mg/L,二者具有显著性差异(P<0.05)。结论急性缺血性脑卒中患者血清中hs-CRP水平较健康人群高,二者差异具有统计学意义(P<0.05);年龄和性别很可能是影响急性缺血性脑卒中患者血清hs-CRP的因素,急性缺血性脑卒中患者中hs-CRP阳性的平均年龄较hs-CRP阴性高,有高血压、糖尿病史的中老年人群发生急性缺血性脑卒中的危险性较健康人群高。更多还原

【Abstract】 Objective To explore the level of hypersensitive C-reactive protein(hs-CRP)in the patients with acute ischemic stroke(AIS)and its clinical significance.Methods The BNⅡ highly sensitive automatical scattering turbidimetric immunity analyzer was adopted to detect serum hs-CRP level in 64 cases of AIS and contemporaneous 32 individuals with healthy physical examination as the control group.The data of AIS cases were retrospectively analyzed.Results The positive rate of hs-CRP was 53.3%in the AIS group and 9%in the control group with statistically significant difference between them(P<0.05);the overall levels of hsCRP in the AIS group was in inconformity to the normal distribution,the median was 4.26mg/L,which in the control group was(0.99±0.72)mg/L,there was statistically significant difference between them(P<0.05);the average level of hs-CRP was(5.03±1.51)mg/L in the AIS male group and(2.79±1.09)mg/L in the AIS female group,the difference between them had statostical significance(P<0.05).Conclusion The serum hs-CRP level in the AIS patients is higher than that in the healthy crowd with statistical difference(P<0.05).The age and sex may be the causes influencing serum level of hs-CRP in the AIS patients.The average age in the AIS patients with positive hs-CRP is higher than that with negative hs-CRP.Middle-aged and elderly people with hypertension and diabetes are much more dangerous than healthy people in getting AIS.更多还原