【摘要】 目的探讨降钙素基因相关肽(CGRP)及白细胞介素1α(IL-1α)在温针治疗腰椎间盘突出症患者前后血清中的变化及临床意义。方法用酶联免疫吸附测定(ELISA)法检测计入统计的60例腰椎间盘突出症患者在温针治疗前后血清及15例健康对照组血清CGRP及IL-1α水平。观察腰椎间盘突出症患者温针治疗前后McGill疼痛量表各项评分及血CGRP、IL-1α水平变化情况。结果腰椎间盘突出症患者针灸治疗后McGill疼痛量表各项评分均明显下降,差异有统计学意义(P<0.01),血清CGRP及IL-1α水平明显降低,差异有统计学意义(P<0.01)。结论 CGRP及IL-1α可以作为针灸治疗腰椎间盘突出症疗效观察指标,为治疗腰椎间盘突出症保守疗法提供依据。更多还原

【Abstract】 Objective To investigate the changes and clinical significance of calcitonin gene related peptide(CGRP)and interleukin 1α(IL-1α)before and after warm acupuncture therapy in the patients with lumbar disc herniation(LDH).Methods Serum CGRP and IL-1αcontents were detected before and after the warm acupuncture therapy in 60cases of lumbar disc herniation and 15 healthy control cases by ELISA method for conducting the statistical analysis.The changes of the McGill pain scores and serum CGRP and IL-1αconcentrations before and after the warm acupuncture therapy were observed.Results The McGill pain scores after the warm acupuncture therapy in the LDH patients were significantly decreased,the difference was statistically significant(P< 0.01),and serum CGRP and IL-1αconcentrations were significantly decreased,the difference was statistically significant(P< 0.01).Conclusion CGRP and IL-1αcan be used as the observation index of the effects for the warm acupuncture therapy in treating LDH,which can provide the basis for the conservative treatment of LDH.更多还原