【摘要】 目的初步探索测量不确定度在临床凝血检验中的应用。方法分析不确定度分量的来源并采用A、B类评定方法,评定本实验室几个常规凝血项目(PT、APTT、FIB)的测量不确定度,合成标准不确定度(uC),计算扩展不确定度(U)。结果常规凝血项目的不确定度不尽相同,PT、APTT、FIB的A类不确定度分别为0.0250、0.0731、0.0280;B类不确定度分量uB1分别为0.0658,0.1478,0.1221;uB2均为0.0070;uB3均为0.0001;uB4均为0.0078;uB5均为0.0177。计算uC(PT)、uC(APTT)、uC(FIB)分别为0.0733、0.1662、0.1269,U(PT)、U(APTT)、U(FIB)分别为0.1466、0.3324、0.2538。结论本研究采用A、B类评定方法,对凝血检验中测量不确定度进行评估,作为临床凝血检验工作的不确定度研究的初步探索,以期为临床诊断、治疗、预后提供更为客观、可靠的依据。更多还原

【Abstract】 Objective This study was aimed to investigate the application of measurement uncertainty in clinical coagulation tests.Methods The source of measurement uncertainty was analyzed,and the conventional coagulation indexes(PT,APTT,FIB) were estimated according to A and B type method.The relative standard uncertainties(uC)were combined,and expanded uncertainty(U)was calculated.Results The measurement uncertainty varied among these indexes,A type uncertainties from PT,APTT, FIB were 0.025 0,0.073 1,0.028 0,respectively;B type uncertainties uB1were 0.065 8,0.147 8,0.122 1for PT,APTT,FIB,respectively;and uB2were all 0.007 0;uB3were all 0.000 1;uB4were all 0.007 8;uB5were all 0.017 7.uC(PT),uC(APTT),uC(FIB)was calculated as 0.073 3,0.166 2,0.126 9,respectively,and U(PT),U(APTT),U(FIB)were 0.1466,0.3324,0.2538respectively.Conclusion A and B type method was used in this study to evaluate measurement uncertainty in coagulation tests,it may provide preliminary exploration of measurement uncertainty in coagulation test,and provide more objective and reliable basis for clinical diagnosis,treatment and prognosis.更多还原