【摘要】 目的对比软通道及硬通道微创手术治疗基底节区脑出血的疗效、安全性。方法 2012年4月至2014年3月,在我院收治的78例首次基底节区脑出血患者中进行了单随机对照临床试验。患者或接受软通道或硬通道微创手术,每组各39例。主要观察指标:术后并发症的发生率,治疗后3个月的格拉斯哥预后评分(Glasgow Outcome Scale,GOS)与死亡率。结果两组在90 d颅内积气的发生率(0.00% vs 0.00%,P=1.00)、再发出血的发生率(5.13%vs 7.69%,P=0.664)、继发颅内血肿的发生率(2.56% vs 5.13%,P=0.556)、颅内感染的发生率(0.00% vs 0.00%,P=1.00)、脑脊液漏的发生率(2.56% vs 2.56%,P=1.000)、死亡率(2.56% vs 2.56%,P=1.000)及治疗后3个月的格拉斯哥预后评分(P=0.993)均无统计学差异。结论软、硬通道微创手术治疗基底节区脑出血均疗效确切,治疗效果相同。更多还原

【Abstract】 Objective To compare the clinical efficacy and safety between soft-channel and hard-channel minimally invasive operations in patients with basal ganglial hemorrhage. Methods A single-blind,randomized controlled clinical trial was performed in 78 patients with the first incidence of basal ganglial hemorrhage who were admitted to our hospital from April 2012 to March 2014. Patients were randomly assigned to receive either soft-channel( n = 39) or hard-channel( n = 39) minimally invasive operations. The primary observation indices were the incidence of postoperative complications,Glasgow Outcome Scale( GOS) score at 3 months after treatment,and mortality rate. Results There were no significant differences in all the following indices between the two groups: incidence rates of pneumocephalus( 0. 00% vs 0. 00%,P = 1. 00),recurrent hemorrhage( 5. 13% vs 7. 69%,P = 0. 664),secondary intracranial hematoma( 2. 56% vs 5. 13%,P = 0. 556),intracranial infection( 0. 00% vs 0. 00%,P = 1. 00),cerebrospinal fluid leakage( 2. 56% vs 2. 56%,P = 1. 000),mortality rate( 2. 56% vs 2. 56%,P = 1. 000),and the GOS score at 3 months after treatment( P = 0. 993). Conclusions The soft-channel and hard-channel minimally invasive operations are equally effective in treating patients with basal ganglial hemorrhage.更多还原