【摘要】 目的:探讨叶酸和维生素B₁₂与阿尔茨海默病精神障碍（BPSD）的相关性。方法:对77例阿尔茨海默病（AD）患者（BPSD组40例,非BPSD组37例）及39例正常对照组进行叶酸和维生素B12测定,并分析其与BPSD及认知功能障碍的关系。结果:BPSD组和非BPSD组血浆叶酸水平明显低于对照组（P<0.05）,而BPSD组与非BPSD组未见明显差异（P>0.05）。BPSD组和非BPSD组血浆维生素B₁₂水平明显低于对照组（P<0.01）,且BPSD组显著低于非BPSD组（P<0.01）。维生素B₁₂水平与认知功能障碍呈正相关（r=0.441,P<0.01）。结论:叶酸及维生素B₁₂水平与BPSD的认知障碍有关。更多还原

【Abstract】 OBJECTIVE:To investigate the correlation among folate,vitamin B₁₂ and behaviral and psychological symptoms of dementia（BPSD）.METHODS;Folate and vitamin B₁₂ were measured in 77 patients with Alzheimer disease（AD）.BPSD group was 40 cases,non- BPSD group was 37 cases and 39 persons were normal controls.The correlation among folate,vitamin B₁₂ levels,BPSD and cognitive impairment were analyzed.RESULTS:①The level of folate was significantly lower in BPSD and non- BPSD group than that in the normal group（P < 0.05）.But there was no significantly difference in BPSD and non BPSD group（P > 0.05）.?The vitamin B₁₂ levels were significantly lower in BPSD and non- BPSD group than that in the normal group,and the level of it in BPSD group was significantly lower than that in non- BPSD group（P <0.01）.There was a positive relation between vitamin B₁₂ levels and cognitive decline of dementia（r = 0.441,P < 0.01）.CONCLUTION:The low levels of folate and vitamin B₁₂are related to the disorder of BPSD.更多还原