AIM:To investigate the main reasons,effects and com plications of penetrating keratoplasty. METHOTS:Retrospective analysis on 150 cases( 150eyes) of penetrating keratoplasty was done from Jan. 2011to June 2013. RESULTS:Reasons:coneal lecuma 99 eyes( 66%);corneal degeneration 18 eyes( 12%); corneal ulcers 15eyes( 10%); corneal endothelium decom pensation 10eyes( 6. 7%); keratoconus 8 eyes( 5. 3%). Effects:Grafts were transparent in 110 eyes( 73. 3%). There are 42 eyes( 28%) less than or equal to 0. 05 in vis...