【摘要】 Single-minded 2(Sim2)蛋白属于碱性螺旋-环-螺族(basic helix-loop-helix,bHLH)家族,是真核生物蛋白质中的一个大家族,其家族成员参与调控血细胞生成、肌细胞生成、神经发生、性别决定等,在生物的生长发育调控过程中发挥着重要作用。研究表明,Sim2调控细胞发育,神经再生,并参与多个器官肿瘤发生;此外,Sim2与中枢神经系统(central nervous system,CNS)退行性疾病及唐氏综合征(Down syndrome,DS)等的发生发展亦密切相关。更多还原

【Abstract】 The protein of Single-minded 2(Sim2)belongs to the bHLH family in eukaryotes.The family members regulate the hematopoiesis,myogenesis,neurogenesis and sex determination,playing an important role in regulating the process of biological growth and development.Studies have shown that Sim2regulates cell growth,nerve regeneration,and involves in multiple tumorigenesis.In addition,Sim2 is also closely related to the development of the central nervous system(CNS)degenerative disease and Down’s syndrome(DS).更多还原