【摘要】 目的探讨食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)中Sox2和β-catenin的表达水平及其临床意义。结果 ESCC组织中Sox2和β-catenin的阳性率分别为62.22%和66.67%,显著高于对照组织的35%和40%(P<0.05);二者之间呈正相关,均与ESCC淋巴结转移、外膜浸润、PTNM分期有关(P<0.05);Sox2阳性患者的5年生存率(8.93%)显著低于阴性患者(70.59%)(P<0.05),二者与患者性别、年龄、肿瘤部位、直径及其分化程度无关(P>0.05)。结论ESCC中Sox2和β-catenin阳性ESCC患者更易发生淋巴结转移和外膜浸润,Sox2阳性患者预后较差。本研究对深入理解ESCC和寻找新的治疗新策略供实验依据。方法采用免疫组织化学方法检测90例ESCC及20例癌旁正常食管黏膜组织(对照)中Sox2和β-catenin蛋白表达水平及其与患者临床病理因素之间的关系。更多还原

【Abstract】 Objective To investigate the expression of Sox2andβ-catenin in human esophageal squamous cell carcinoma(ESCC)and their clinical significance.Methods The expression of Sox2andβ-catenin proteins in 90ESCC specimens and 20normal esophageal tissues(controls)was tested by immunostaining.The relationship of Sox2andβ-catenin with clinicopathological parameters of patients with ESCC was also analysed.Results The positive rates of Sox2andβ-catenin in ESCC were 62.22%and 66.67%,respectively, which were significantly higher than those in the controls of 35% and 40%,respectively(P<0.05). There was a positive association between Sox2andβ-catenin,and the expression of both proteins was associated with lymph node metastasis,serosa-infiltration and PTNM stage(P<0.05for all).The 5-year survival rates of patients with positive Sox2was 8.93%,worse than those with negative Sox2(70.59%)(P <0.05).Neither Sox2norβ-catenin was associated with gender or age of patients,or the anatomic location,gross type,diameter or differentiation of tumor(P>0.05for all).Conclusion ESCC patients with positive Sox2andβ-catenin are at higher risk of serosa invasion and lymph node metastasis than those with negative Sox2andβ-catenin.The prognosis of patients with positive Sox2is worse than those with negative Sox2.This study may help understand ESCC thoroughly and is of theoretical and practical significance for discovering new target points of treating ESCC.更多还原