【摘要】 目的了解广州市男性居民吸烟对其肺功能以及体内多环芳烃代谢物水平的影响。方法 2012年7月采用系统抽样方法在广州市黄埔区和增城市各抽取1个社区中45岁以上的男性常住居民作为研究对象,资料收集包括问卷调查、晨尿中10种羟基多环芳烃浓度检测和肺功能检测。采用协方差和多重线性回归分析吸烟、肺功能以及尿液中羟基多环芳烃浓度之间的关系。结果本次研究共纳入142名研究对象,平均年龄为(61.30±9.73)岁,其中吸烟者94人(66.20%)。协方差分析控制混杂因素后发现吸烟者肺功能指标1秒率(F=6.84)、用力呼气中段流量(F=5.52)和最大通气量(F=4.54)低于不吸烟者,且尿液中1-羟基萘(F=10.21)、2-羟基萘(F=8.74)和2-+3-羟基芴(F=4.11)浓度高于不吸烟者(P<0.05或P<0.01)。2-羟基菲、3-羟基菲、4-羟基菲、1-羟基芘与峰流速呈负相关(β=-6.34、-6.39、-5.44、-5.03),2-羟基萘与用力呼气中段流量呈负相关(β=-5.91),1-羟基萘、2-羟基萘与最大通气量呈负相关(β=-2.85、-3.11),均P<0.05。结论广州地区男性居民吸烟可降低肺功能并增加多环芳烃的内暴露水平,体内多环芳烃增加与肺功能下降存在相关关系。更多还原

【Abstract】 Objective To investigate the effects of smoking on pulmonary function and urinary concentrations of polycyclic aromatic hydrocarbon( PAH) metabolites among male adults in Guangzhou.Methods A systematic sampling method was employed to select male adults in Huangpu District and Zengcheng during July 2012. All subjects were aged 45 years and over,lived in the location more than half year,and interviewed with the questionnaire. Ten OH-PAHs in urine and pulmonary functions were tested.Covariance and multiple linear regression analyses were employed to test relationships between smoking,pulmonary functions and OH-PAH concentrations. Results A total of 142 male adults were recruited whose average age was( 61. 30 ± 9. 73) years. Ninety four of them were smokers( 66. 20%). The covariance analyses revealed that the FEV1/FVC( F = 6. 84),FEF25- 75( F =5.52) and MVV( F =4.54) were lower in smokers than those in none-smokers( P < 0. 05 for all). Smokers had higher concentrations of urinary 1-OHNa( F = 10. 21),2-OHNa( F = 8. 74) and 2-+ 3-OHFlu( F = 4. 11) than none-smokers( P <0.05 or P < 0.01). Furthermore,2-OHPhe( β =- 6.34),3-OHPhe( β =- 6.39),4-OHPhe( β =-5.44),and 1-OHP( β =- 5.03) had negative relationships with PEF( P < 0.05 for all);2-OHNa had negative relationship with FEF25- 75( β =- 5.91,P < 0.05); 1-OHNa( β =- 2.85) and2-OHNa( β =- 3. 11) had significantly negative relationships with MVV( P < 0. 05 for all). Conclusion Smoking could reduce pulmonary functions of male adults in Guangzhou and increase their internal exposure to PAHs. The internal increase in PAHs was related to the declined pulmonary functions.更多还原