【摘要】 抗菌肽是机体天然免疫系统的重要组成部分,因具有抗菌谱广、活性稳定、不易产生耐药性等优点而在食品、饲料、农业、医药领域具有重要的应用价值。由于化学合成的成本较高,利用基因工程技术构建高效的生物表达系统成为一个新的途径。综述了抗菌肽在细菌、酵母、植物、动物等表达系统中异源表达的研究进展,为抗菌肽的研究应用提供理论依据。更多还原

【Abstract】 Antimicrobial peptides(AMPs) are an important component of the innate immune system of organisms.Owing to their potent,broad-spectrum antibacterial activities and uneasy developing of drug resistance,these peptides have great clinical significance.However,preparation of AMPs at a large scale is a severe challenge to the development of commercial products.Undoubtedly,construction of high-level biological expression systems for the production of AMPs is the key in its clinical application process.This paper summarizes the research progress on heterogenous expression of AMPs in prokaryotic expression systems and eukaryotic expression systems,in order to provide a certain theoretical basis for research and application of AMPs.更多还原