【摘要】 采用正则模式分析了杀线虫苏云金芽孢杆菌毒素Cry5Aa的柔韧性,计算了正则模式模拟毒素的主成分,B-因子、蛋白质铰链点和氨基酸残基相关性,结果表明,Cry5Aa结构域Ⅰα2螺旋一段插入序列具有较大的柔韧性,其运动与其他氨基酸残基的相关性较小。更多还原

【Abstract】 Normal mode analysis was used to study the flexibility of nematicidal Cry5Aaof Bacillus thuringiensis. The principal components, B-factors, hinge points and residue correlations were calculated and detected. Results showed that the special insertion structure of helixα2 of domainⅠof the toxin has the higher flexibility. It has low motion correlation with the other residues of the toxin更多还原