【摘要】 目的:探讨钆贝葡胺注射液外预热对对比剂不良反应(ADR)发生率以及对患者心率、血压的影响,从而为临床上钆贝葡胺的安全使用提供依据。方法:将拟行磁共振灌注加权成像(MRPWI)的711例受检者随机分为预热组(508例)和常温组(203例)。预热组中在使用钆贝葡胺注射液前先将其放入36℃的恒温箱10~15min,常温组中使用检查室内常温下(扫描室恒定温度22℃左右)放置的钆贝葡胺注射液。对比剂剂量0.1mmol/kg,注射流率2.0~2.5mL/s,经高压注射器推注。观察并记录患者ADR发生情况,同时记录在对比剂注射前、后预热组中111例患者及常温组中99例患者的临床生理指标(心率、血压,体温等),计算其差值,并进行统计学分析。结果:预热组的ADR发生率为0.2%(1/508),明显低于常温组(3%,6/203),两组间差异有统计学意义(P<0.05)。注射对比剂前后,常温组中患者的心率波动为(-0.41±6.84)次/分,大于预热组患者[(-2.34±5.76)次/分],两组间差异有统计学意义(P<0.05);常温组患者的舒张压波动[(-0.05±10.24)mmHg]明显大于预热组[(3.56±10.13)mmHg],两组间差异有统计学意义(P<0.05);两组患者体温波动的差异无统计学意义(P>0.05)。结论:钆贝葡胺注射液的外预热可有效降低ADR发生率且对患者心率、血压的影响较小。更多还原

【Abstract】 Objective:To explore the effects of warming of gadobenate dimeglemine injection before injection on adverse drug reaction(ADR)and heart rate(HR)and blood pressure of patients in magnetic resonance perfusion imaging,and then provide evidence for safe clinical application of gadobenate dimeglemine.Methods:According to warming of gadobenate dimeglemine or not,711 patients were randomly divided into warming group(508cases)and control group(203cases).In warming group,the contrast medium was put into thermostat at 36℃,while in control group the contrast medium placed in scanning room was used without warming before injection(the temperature in scanning room was kept at 22℃).Before magnetic resonance perfusion imaging,gadobenate dimeglemine injection(0.1mmol/kg or 0.2ml/kg)was injected with flow rate of 2.0~2.5mL/s by a Medrad high-pressure syringe.The ADR of patients was observed and recorded,meanwhile physiological indicators(including heart rate,blood pressure and body temperature)of 111 cases in warming group and 99 cases in control group were recorded before and after injection of contrast medium,the difference of those indicators before and after injection was calculated and analyzed by independent sample t-test.Results:The incidence of ADR in warming group(1/508,0.2%)was significantly lower than that in control group(6/203,3%),with statistic differences(P<0.05);the changes of heart rates in the control group[(-0.41±6.84)bpm]were greater than that in warming group[(-2.34±5.76)bpm],with statistical difference(P<0.05);the changes of systolic blood pressures in the control group[(-0.05±10.24)mmHg]were significantly greater than that in warming group[(3.56±10.13)mmHg],with statistical difference(P<0.05);no significant difference was observed in the change of body temperature before and after injection in the two groups.Conclusion::warming of gadobenate dimeglemine injection can significantly reduce the incidences of ADR in magnetic resonance perfusion imaging examination,and causes less effect on heart rate and blood pressure.更多还原