【摘要】 目的探讨耳鸣患者脑PET18F-FDG代谢的相关脑区。方法通过对41例耳鸣患者及40例健康对照组进行PET-CT检查,行踪剂为18 F-FDG,结果用统计参数图(SPM)软件进行统计分析,确定与耳鸣相关脑区的解剖部位(BA)。结果耳鸣患者相关脑区主要位于左侧颞下回(BA20)、左侧颞中回(BA21)、左侧颞上回(BA22)、左侧腹侧后扣带皮层(BA24)、左侧颞极区(BA38)及右侧后外侧前额叶皮层(BA9)、右侧额极区(BA10)、右侧眶额回(BA11)、右侧颞下回(BA20)、右侧背侧前扣带皮层(BA32)、右侧海马旁皮层(BA36)、右侧梭状回(BA37)。结论耳鸣患者在中枢神经系统可能存在特定的投射区,主要位于边缘系统及额叶联合区,与主次级听觉皮层有一定关系。PET为耳鸣提供了客观证据,有望成为耳鸣的客观检测方法。更多还原

【Abstract】 Objective To investigate central correlates of tinnitus perception in brain imaging.Methods Brain position emission tomography(PET)tests were performed on the tinnitus patients and controls.The effects of laterality were evaluated with statistical parametric mapping(SPM)in whole brain analyses.Results The study showed that the most consistently activated regions in tinnitus subjects,compared with controls,were left inferior temporal cortex(BA20),left middle temporal gyrus(BA21),left superior temporal(BA22),left Ventral Anterior cingulate cortex(BA24),left Temporopolar area(BA38),right dorsal anterior cingulated cortex(BA9),right Anterior prefrontal cortex(BA10),right Orbitofrontal area(BA11),right inferior temporal cortex(BA20),right Dorsal anterior cingulate cortex(BA32),right parahippocampal Cortex(BA36)and right Fusiform gyrus(BA37).Conclusion This study proves that PET is a useful modality for tinnitus research and solidifies human tinnitus research itself by confirming previously described brain areas involved in the generation and maintenance of tinnitus.更多还原