【摘要】 目的初步研究板桥党参多糖的抗肿瘤活性。方法 MTT法检测板桥党参多糖体外抗肿瘤活性。对S180荷瘤小鼠灌胃板桥党参多糖,观察肿瘤的生长抑制情况。以最大给药量法对小鼠进行灌胃给药测定板桥党参多糖的急性毒性。结果板党多糖对MCF-7细胞具有显著抑制增殖作用;荷瘤小鼠小、中、大剂量组肿瘤质量明显小于模型对照组(P<0.05),小鼠以最大剂量灌胃给药后全部存活。结论板党多糖具有抑制肿瘤生长的作用。更多还原

【Abstract】 Objective To investigate the antitumor activity of Polysaccharides from Codonopsis tangshen. Methods Detection of anti-tumor activity in vitro was based on MTT assay,and the analysis in vivo was based on S180 tumor-bearing mice fed on Polysaccharides from Codonopsis tangshen. Acute toxicity was observed on mice with maximum dose. Results Polysaccharides from Codonopsis tangshen significantly inhibited the proliferation of MCF- 7 cells,tumor mass from tumor- bearing mice with small,medium, large doses was significantly smaller than that of the model group( P<0. 05). Acute toxicity test mice survived. Conclusion Polysaccharides from Codonopsis tangshen significantly inhibited tumor growth.更多还原