【摘要】 随着新的CD4~+T淋巴细胞亚群的不断发现,人们对结核病免疫的认识也在不断的更新之中。辅助性T细胞(T helper cell,Th)17是一群分泌白介素(IL)-17的不同于Th1、Th2和调节性T细胞的一类新型CD4~+T细胞亚群,新近被发现具有不同细胞表型。早期研究认为,IL-17和Th17细胞在自身免疫性疾病中起重要作用。近来发现在抗结核分枝杆菌感染免疫中也起着重要作用,但具体发挥免疫保护作用还是免疫病理作用尚存争议。本文就IL-17、Th17细胞在结核病免疫应答中的作用及其调控进行综述,以便今后在抗结核治疗中引入新的特异性免疫治疗。更多还原

【Abstract】 Along with the discovery of new CD4~+T-cell subsets has the concepts of immune response to tuberculosis renewed.T helper cell(Th)17 that secretes interleukin(IL)-17,which is a novel subset of CD4~+T-cell different from Th1,Th2 and other regulatory t cells.It is found recently that there is a wide spectrum of Th17 phenotypes with differences in their cytokine production and effector functions.Early study suggests IL-17 and Th17 play critical roles in autoimmune diseases.Recent data suggest they play important roles in fighting Mycobacterium tuberculosis(Mtb)infection,but whether protective immunity or mediate immunopathology in response to Mtb infection is still controversial.In this review,we summarize the roles and the regulations of immune response of IL-17 and Th17 to tuberculosis.Understanding these mechanisms will enable us to develop specific immunotherapy against Mtb infection.更多还原